Protecting the endothelial glycocalyx in COVID-19

Emira Adam Tay, Vimmal Vijayakumar, Raika Francesca Morales, Ee Soo Lee, Andrew Teo

PLOS Pathogens: published May 16, 2024 | https://doi.org/10.1371/journal.ppat.1012203

Tools for pathogen genetic surveillance: Lessons from the ash dieback invasion of Europe

Jessica A. Peers, Richard M. Leggett, Matthew D. Clark, Mark McMullan

PLOS Pathogens: published May 23, 2024 | https://doi.org/10.1371/journal.ppat.1012182

Genome variation in the Batrachochytrium pathogens of amphibians

Theresa Wacker, Nicolas Helmstetter, David J. Studholme, Rhys A. Farrer

PLOS Pathogens: published May 23, 2024 | https://doi.org/10.1371/journal.ppat.1012218

Effects of climate change on fungal infections

Samantha L. Williams, Mitsuru Toda, Tom Chiller, Joan M. Brunkard, Anastasia P. Litvintseva

PLOS Pathogens: published May 30, 2024 | https://doi.org/10.1371/journal.ppat.1012219

Microbial extracellular vesicles contribute to antimicrobial resistance

Bowei Jiang, Yi Lai, Wenhao Xiao, Tianyu Zhong, Fengping Liu, Junjie Gong, Junyun Huang

PLOS Pathogens: published May 2, 2024 | https://doi.org/10.1371/journal.ppat.1012143

Crosstalk between circadian clocks and pathogen niche

Helene Borrmann, Filipa Rijo-Ferreira

PLOS Pathogens: published May 9, 2024 | https://doi.org/10.1371/journal.ppat.1012157

Major Group-B Enterovirus populations deleted in the noncoding 5’ region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis

Domitille Callon, Marie Glenet, Anne-Laure Lebreil, Laetitia Heng, Nicole Bouland, Caroline Fichel, Paul Fornes, Laurent Andreoletti, Fatma Berri

PLOS Pathogens: published May 2, 2024 | https://doi.org/10.1371/journal.ppat.1012125

HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa

Etthel M. Windels, Eddie M. Wampande, Moses L. Joloba, W. Henry Boom, Galo A. Goig, Helen Cox, Jerry Hella, Sonia Borrell, Sebastien Gagneux, Daniela Brites, Tanja Stadler

PLOS Pathogens: published May 2, 2024 | https://doi.org/10.1371/journal.ppat.1011675

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection

Weihao Zheng, I-Chang Chang, Jason Limberis, Jonathan M. Budzik, Beth Shoshana Zha, Zachary Howard, Lucas Chen, Joel D. Ernst

PLOS Pathogens: published May 3, 2024 | https://doi.org/10.1371/journal.ppat.1012205

FgPfn participates in vegetative growth, sexual reproduction, pathogenicity, and fungicides sensitivity via affecting both microtubules and actin in the filamentous fungus Fusarium graminearum

Zhili Yuan, Pengfei Li, Xin Yang, Xiaowei Cai, Luoyu Wu, Feifei Zhao, Weidong Wen, Mingguo Zhou, Yiping Hou

PLOS Pathogens: published May 3, 2024 | https://doi.org/10.1371/journal.ppat.1012215

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

Somya Aggarwal, Forrest C. Walker, James S. Weagley, Broc T. McCune, Xiaofen Wu, Lawrence A. Schriefer, Heyde Makimaa, Dylan Lawrence, Pratyush Sridhar, Megan T. Baldridge

PLOS Pathogens: published May 3, 2024 | https://doi.org/10.1371/journal.ppat.1011961

CCR5 promotes the migration of pathological CD8⁺ T cells to the leishmanial lesions

Laís Amorim Sacramento, Camila Farias Amorim, Claudia G. Lombana, Daniel Beiting, Fernanda Novais, Lucas P. Carvalho, Edgar M. Carvalho, Phillip Scott

PLOS Pathogens: published May 6, 2024 | https://doi.org/10.1371/journal.ppat.1012211

Structural basis for raccoon dog receptor recognition by SARS-CoV-2

Fu-Chun Hsueh, Ke Shi, Alise Mendoza, Fan Bu, Wei Zhang, Hideki Aihara, Fang Li

PLOS Pathogens: published May 6, 2024 | https://doi.org/10.1371/journal.ppat.1012204

The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited

Mounia Lahfa, Philippe Barthe, Karine de Guillen, Stella Cesari, Mouna Raji, Thomas Kroj, Marie Le Naour—Vernet, François Hoh, Pierre Gladieux, Christian Roumestand, Jérôme Gracy, Nathalie Declerck, André Padilla

PLOS Pathogens: published May 6, 2024 | https://doi.org/10.1371/journal.ppat.1012176

Ethanolamine metabolism through two genetically distinct loci enables Klebsiella pneumoniae to bypass nutritional competition in the gut

Andrew J. Barnes, Emma F. Bennett, Ben Vezina, Andrew W. Hudson, Giovanna E. Hernandez, Noah A. Nutter, Andrew S. Bray, Ravinder Nagpal, Kelly L. Wyres, M. Ammar Zafar

PLOS Pathogens: published May 7, 2024 | https://doi.org/10.1371/journal.ppat.1012189

sRNA expression profile of KPC-2-producing carbapenem-resistant Klebsiella pneumoniae: Functional role of sRNA51

Yibo Bai, Chonghong Xie, Yue Zhang, Zhijie Zhang, Jianhua Liu, Guixue Cheng, Yan Li, Di Wang, Bing Cui, Yong Liu, Xiaosong Qin

PLOS Pathogens: published May 8, 2024 | https://doi.org/10.1371/journal.ppat.1012187

Impaired upper respiratory tract barrier function during postnatal development predisposes to invasive pneumococcal disease

Kristen L. Lokken-Toyli, Surya D. Aggarwal, Gavyn Chern Wei Bee, Wouter A. A. de Steenhuijsen Piters, Cindy Wu, Kenny Zhi Ming Chen, Cynthia Loomis, Debby Bogaert, Jeffrey N. Weiser

PLOS Pathogens: published May 8, 2024 | https://doi.org/10.1371/journal.ppat.1012111

Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restriction

Ryan D. Pardy, Katelyn A. Walzer, Bethan A. Wallbank, Jessica H. Byerly, Keenan M. O’Dea, Ian S. Cohn, Breanne E. Haskins, Justin L. Roncaioli, Eleanor J. Smith, Gracyn Y. Buenconsejo, Boris Striepen, Christopher A. Hunter

PLOS Pathogens: published May 8, 2024 | https://doi.org/10.1371/journal.ppat.1011820

Serine protease Rv2569c facilitates transmission of Mycobacterium tuberculosis via disrupting the epithelial barrier by cleaving E-cadherin

Xinxin Zang, Jiajun Zhang, Yanyan Jiang, Tingting Feng, Yingying Cui, Hui Wang, Ziyin Cui, Guanghui Dang, Siguo Liu

PLOS Pathogens: published May 9, 2024 | https://doi.org/10.1371/journal.ppat.1012214

Metabolic changes enhance necroptosis of type 2 diabetes mellitus mice infected with Mycobacterium tuberculosis

Abhinav Vankayalapati, Olamipejo Durojaye, Tanmoy Mukherjee, Padmaja Paidipally, Bismark Owusu-Afriyie, Ramakrishna Vankayalapati, Rajesh Kumar Radhakrishnan

PLOS Pathogens: published May 10, 2024 | https://doi.org/10.1371/journal.ppat.1012148

Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters

Megan Levy, Jessica W. Chen, Jaclyn A. Kaiser, Hong-Su Park, Xueqiao Liu, Lijuan Yang, Celia Santos, Ursula J. Buchholz, Cyril Le Nouën

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1012198

Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7

Chuang Li, Jiaqi Fu, Shuai Shao, Zhao-Qing Luo

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1011783

Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3

Zhi Li, Jun Li, Ziyi Li, Yanan Song, Yanyi Wang, Chunling Wang, Le Yuan, Wuhan Xiao, Jing Wang

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1012227

A conserved switch controls virulence, sporulation, and motility in C. difficile

Michael A. DiCandia, Adrianne N. Edwards, Ysabella B. Alcaraz, Marcos P. Monteiro, Cheyenne D. Lee, Germán Vargas Cuebas, Pritha Bagchi, Shonna M. McBride

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1012224

Protective role of RIPK1 scaffolding against HDV-induced hepatocyte cell death and the significance of cytokines in mice

Gracián Camps, Sheila Maestro, Laura Torella, Diego Herrero, Carla Usai, Martin Bilbao-Arribas, Ana Aldaz, Cristina Olagüe, Africa Vales, Lester Suárez-Amarán, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1011749

Biofilm-associated metabolism via ERG251 in Candida albicans

Liping Xiong, Nivea Pereira De Sa, Robert Zarnowski, Manning Y. Huang, Caroline Mota Fernandes, Frederick Lanni, David R. Andes, Maurizio Del Poeta, Aaron P. Mitchell

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1012225

Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques

Cordelia Manickam, Amit A. Upadhyay, Griffin Woolley, Kyle W. Kroll, Karen Terry, Courtney A. Broedlow, Nichole R. Klatt, Steven E. Bosinger, R. Keith Reeves

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1012223

Modulation of host lipid metabolism by virus infection leads to exoskeleton damage in shrimp

Xin-Xin Wang, Ming-Jie Ding, Jie Gao, Ling Zhao, Rong Cao, Xian-Wei Wang

PLOS Pathogens: published May 13, 2024 | https://doi.org/10.1371/journal.ppat.1012228

Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions

Yuejin Liang, Hui Wang, Keer Sun, Jiaren Sun, Lynn Soong

PLOS Pathogens: published May 14, 2024 | https://doi.org/10.1371/journal.ppat.1012020

Deciphering infected cell types, hub gene networks and cell-cell communication in infectious bronchitis virus via single-cell RNA sequencing

Chengyin Liukang, Jing Zhao, Jiaxin Tian, Min Huang, Rong Liang, Ye Zhao, Guozhong Zhang

PLOS Pathogens: published May 14, 2024 | https://doi.org/10.1371/journal.ppat.1012232

Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery

Aaron Embry, Nina S. Baggett, David B. Heisler, Addison White, Maarten F. de Jong, Benjamin L. Kocsis, Diana R. Tomchick, Neal M. Alto, Don B. Gammon

PLOS Pathogens: published May 16, 2024 | https://doi.org/10.1371/journal.ppat.1012010

Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking

Stefano Bonazza, Hannah Leigh Coutts, Swathi Sukumar, Hannah Louise Turkington, David Gary Courtney

PLOS Pathogens: published May 16, 2024 | https://doi.org/10.1371/journal.ppat.1012231

The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole

Paul D. E. Williams, Matthew T. Brewer, Raffi V. Aroian, Alan P. Robertson, Richard J. Martin

PLOS Pathogens: published May 17, 2024 | https://doi.org/10.1371/journal.ppat.1011835

Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus

Wim P. Burmeister, Laetitia Boutin, Aurelia C. Balestra, Henri Gröger, Allison Ballandras-Colas, Stephanie Hutin, Christian Kraft, Clemens Grimm, Bettina Böttcher, Utz Fischer, Nicolas Tarbouriech, Frédéric Iseni

PLOS Pathogens: published May 20, 2024 | https://doi.org/10.1371/journal.ppat.1011652

A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection

Jessica Ciesla, Kai-Lieh Huang, Eric J. Wagner, Joshua Munger

PLOS Pathogens: published May 20, 2024 | https://doi.org/10.1371/journal.ppat.1012058

Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage

Nidhi Shukla, Sarah M. Roelle, John C. Snell, Olivia DelSignore, Anna M. Bruchez, Kenneth A. Matreyek

PLOS Pathogens: published May 20, 2024 | https://doi.org/10.1371/journal.ppat.1012044

Infectious hepatitis E virus is associated with the mature sperm head

Kush K. Yadav, Patricia A. Boley, Thamonpan Laocharoensuk, Saroj Khatiwada, Carolyn M. Lee, Menuka Bhandari, Lindsey Moore, Juliette Hanson, Scott P. Kenney

PLOS Pathogens: published May 20, 2024 | https://doi.org/10.1371/journal.ppat.1012240

Quantifying the fitness effects of resistance alleles with and without anthelmintic selection pressure using Caenorhabditis elegans

Amanda O. Shaver, Isabella R. Miller, Etta S. Schaye, Nicolas D. Moya, J. B. Collins, Janneke Wit, Alyssa H. Blanco, Fiona M. Shao, Elliot J. Andersen, Sharik A. Khan, Gracie Paredes, Erik C. Andersen

PLOS Pathogens: published May 20, 2024 | https://doi.org/10.1371/journal.ppat.1012245

Dampening of ISGylation of RIG-I by ADAP regulates type I interferon response of macrophages to RNA virus infection

Yan Wang, Haixia Feng, Xiao Li, Yina Ruan, Yueping Guo, Xinxing Cui, Pengchao Zhang, Yanli Li, Xinning Wang, Xingran Wang, Luxin Wei, Yulan Yi, Lifeng Zhang, Xiaodong Yang, Hebin Liu

PLOS Pathogens: published May 22, 2024 | https://doi.org/10.1371/journal.ppat.1012230

Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control activated viral gene expression

Emmanuelle Wilhelm, Mikaël Poirier, Morgane Da Rocha, Mikaël Bédard, Patrick P. McDonald, Pierre Lavigne, Christie L. Hunter, Brendan Bell

PLOS Pathogens: published May 23, 2024 | https://doi.org/10.1371/journal.ppat.1011821

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

Marisa E. McGrath, Yong Xue, Louis Taylor, Carly Dillen, Jeremy Ardanuy, Norberto Gonzalez-Juarbe, Lauren Baracco, Raymond Kim, Rebecca Hart, Nacyra Assad-Garcia, Sanjay Vashee, Matthew B. Frieman

PLOS Pathogens: published May 23, 2024 | https://doi.org/10.1371/journal.ppat.1011669

Mycoplasma glycine cleavage system key subunit GcvH is an apoptosis inhibitor targeting host endoplasmic reticulum

Qiao Pan, Yujuan Zhang, Tong Liu, Qingyuan Xu, Qi Wu, Jiuqing Xin

PLOS Pathogens: published May 24, 2024 | https://doi.org/10.1371/journal.ppat.1012266

Fungi and bacteria occupy distinct spatial niches within carious dentin

Rosalyn M. Sulyanto, Clifford J. Beall, Kasey Ha, Joseph Montesano, Jason Juang, John R. Dickson, Shahr B. Hashmi, Seth Bradbury, Eugene J. Leys, Mira Edgerton, Sunita P. Ho, Ann L. Griffen

PLOS Pathogens: published May 28, 2024 | https://doi.org/10.1371/journal.ppat.1011865

Meta-analysis of Epstein-Barr virus genomes in Southern Chinese identifies genetic variants and high risk viral lineage associated with nasopharyngeal carcinoma

Ka Wo Wong, Kwai Fung Hui, Ki Pui Lam, Dora Lai-wan Kwong, Maria Li Lung, Wanling Yang, Alan K. S. Chiang

PLOS Pathogens: published May 28, 2024 | https://doi.org/10.1371/journal.ppat.1012263

Neoblast-like stem cells of Fasciola hepatica

Paul McCusker, Nathan G. Clarke, Erica Gardiner, Rebecca Armstrong, Erin M. McCammick, Paul McVeigh, Emily Robb, Duncan Wells, Madelyn Nowak-Roddy, Abdullah Albaqami, Angela Mousley, Jonathan A. Coulter, John Harrington, Nikki J. Marks, Aaron G. Maule

PLOS Pathogens: published May 28, 2024 | https://doi.org/10.1371/journal.ppat.1011903

Macrophage- and CD4⁺ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity

Christina B. Karsten, Falk F. R. Buettner, Samanta Cajic, Inga Nehlmeier, Berit Roshani, Antonina Klippert, Ulrike Sauermann, Nicole Stolte-Leeb, Udo Reichl, Rita Gerardy-Schahn, Erdmann Rapp, Christiane Stahl-Hennig, Stefan Pöhlmann

PLOS Pathogens: published May 28, 2024 | https://doi.org/10.1371/journal.ppat.1012190

Variation in structural motifs within SARS-related coronavirus spike proteins

Francesca R. Hills, Alice-Roza Eruera, James Hodgkinson-Bean, Fátima Jorge, Richard Easingwood, Simon H. J. Brown, James C. Bouwer, Yi-Ping Li, Laura N. Burga, Mihnea Bostina

PLOS Pathogens: published May 28, 2024 | https://doi.org/10.1371/journal.ppat.1012158

Impact of viral telomeric repeat sequences on herpesvirus vector vaccine integration and persistence

Caroline Denesvre, Yu You, Sylvie Rémy, Tereza Vychodil, Katia Courvoisier, Zoltán Penzes, Luca D. Bertzbach, Ahmed Kheimar, Benedikt B. Kaufer

PLOS Pathogens: published May 28, 2024 | https://doi.org/10.1371/journal.ppat.1012261

Winners vs. losers: Schistosoma mansoni intestinal and liver eggs exhibit striking differences in gene expression and immunogenicity

Kristýna Peterková, Lukáš Konečný, Tomáš Macháček, Lucie Jedličková, Franziska Winkelmann, Martina Sombetzki, Jan Dvořák

PLOS Pathogens: published May 30, 2024 | https://doi.org/10.1371/journal.ppat.1012268

OTUB1 contributes to the stability and function of Influenza A virus NS2

Yu-Jyun Li, Chi-Yuan Chen, Yu-Shen Kuo, Yi-Wen Huang, Rei-Lin Kuo, Li-Kwan Chang, Jeng-How Yang, Chih-Ho Lai, Shin-Ru Shih, Ya-Fang Chiu

PLOS Pathogens: published May 30, 2024 | https://doi.org/10.1371/journal.ppat.1012279

The Toxoplasma gondii F-Box Protein L2 Functions as a Repressor of Stage Specific Gene Expression

Carlos G. Baptista, Sarah Hosking, Elisabet Gas-Pascual, Loic Ciampossine, Steven Abel, Mohamed-Ali Hakimi, Victoria Jeffers, Karine Le Roch, Christopher M. West, Ira J. Blader

PLOS Pathogens: published May 30, 2024 | https://doi.org/10.1371/journal.ppat.1012269

A novel ilarvirus protein CP-RT is expressed via stop codon readthrough and suppresses RDR6-dependent RNA silencing

Nina Lukhovitskaya, Katherine Brown, Lei Hua, Adrienne E. Pate, John P. Carr, Andrew E. Firth

PLOS Pathogens: published May 30, 2024 | https://doi.org/10.1371/journal.ppat.1012034

Pseudomonas aeruginosa senses and responds to epithelial potassium flux via Kdp operon to promote biofilm

Glenn J. Rapsinski, Lia A. Michaels, Madison Hill, Kaitlin D. Yarrington, Allison L. Haas, Emily J. D’Amico, Catherine R. Armbruster, Anna Zemke, Dominique Limoli, Jennifer M. Bomberger

PLOS Pathogens: published May 31, 2024 | https://doi.org/10.1371/journal.ppat.1011453

Correction: Magnaporthe oryzae fimbrin organizes actin networks in the hyphal tip during polar growth and pathogenesis

Yuan-Bao Li, Rui Xu, Chengyu Liu, Ningning Shen, Li-Bo Han, Dingzhong Tang

PLOS Pathogens: published May 6, 2024 | https://doi.org/10.1371/journal.ppat.1012210

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Correction: Enterovirus 71 Protease 2A^pro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

Bei Wang, Xueyan Xi, Xiaobo Lei, Xiaoyan Zhang, Sheng Cui, Jianwei Wang, Qi Jin, Zhendong Zhao

PLOS Pathogens: published May 6, 2024 | https://doi.org/10.1371/journal.ppat.1012209

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Retraction: Induction of Interferon-Stimulated Genes by IRF3 Promotes Replication of Toxoplasma gondii

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PLOS Pathogens: published May 31, 2024 | https://doi.org/10.1371/journal.ppat.1012264

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Editorial Note: Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

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PLOS Pathogens: published May 6, 2024 | https://doi.org/10.1371/journal.ppat.1012213

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