At different stages of any research project, molecular biologists need to choose—often
somewhat arbitrarily, even after careful statistical data analysis—which genes or proteins to …

Next generation sequencing can be used to search for Mendelian disease genes in an
unbiased manner by sequencing the entire protein-coding sequence, known as the exome …

Single nucleotide variants represent a prevalent form of genetic variation. Mutations in the
coding regions are frequently associated with the development of various genetic diseases …

Motivation: Widespread availability of low-cost, full genome sequencing will introduce new
challenges for bioinformatics. Results: This review outlines recent developments in …

Precision medicine will revolutionize the way we treat and prevent disease. A major barrier
to the implementation of precision medicine that clinicians and translational scientists face is …

The candidate gene approach has been a pioneer in the field of genetic epidemiology,
identifying risk alleles and their association with clinical traits. With the advent of rapidly …

Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset psychiatric
disorder with high heritability. In recent years, numerous molecular genetic studies have …

Background Elucidating the genetic basis of human diseases is a central goal of genetics
and molecular biology. While traditional linkage analysis and modern high-throughput …

A genetic disorder is a serious disease that affects a large number of individuals around the
world. There are various types of genetic illnesses, however, we focus on mitochondrial and …

Cancer is a complex and heterogeneous disease that exhibits high levels of robustness
against various therapeutic interventions. It is a constellation of diverse and evolving …