%0 Journal Article
%T A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France
%+ Santé publique France - French National Public Health Agency [Saint-Maurice, France]
%+ Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique Innovation et Méthodologie [CHU Nîmes] (BESPIM)
%+ Direction santé environnement travail - Santé Publique France (DSET)
%+ Santé publique France, Cellule Régionale Pays de la Loire [Nantes, France]
%+ Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 (RADEME)
%+ EPI-PHARE (EPI-PHARE)
%+ Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB)
%+ Bordeaux population health (BPH)
%+ Direction des alertes et des vigilances sanitaires (DAVS)
%+ Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
%+ CEMC-Auvergne
%+ Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)
%+ Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138))
%+ Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies (URP 2496)
%+ Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
%+ Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE)
%+ Hôtel-Dieu de Nantes
%+ Hôpitaux de Saint Maurice (HNSM)
%+ Lillebaelt Hospital [Kolding, Denmark] (LH)
%+ Centre Hospitalier Simone Veil (CH Simone Veil)
%+ Conservatoire National des Arts et Métiers [CNAM] (CNAM)
%+ Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS)
%+ Equipe SPHERE (CERPOP)
%+ Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE)
%+ Biodiversité, Gènes & Communautés (BioGeCo)
%+ St George's, University of London
%+ CHU Rouen
%+ Université de Liège
%+ AP-HP Hôpital universitaire Robert-Debré [Paris]
%+ Santé publique France Provence-Alpes-Côte d'azur et Corse - Provence-Alps-French Riviera and Corsica [Marseille]
%+ AP-HP - Hôpital Antoine Béclère [Clamart]
%A Boudet-Berquier, Julie
%A Demattei, Christophe
%A Guldner, Laurence
%A Gallay, Anne
%A Manouvrier, Sylvie
%A Botton, Jérémie
%A Philippat, Claire
%A Delva, Fleur
%A Bloch, Juliette
%A Semaille, Caroline
%A Odent, Sylvie
%A Perthus, Isabelle
%A Randrianaivo, Hanitra
%A Babajko, Sylvie
%A Barjat, Tiphaine
%A Beneteau, Claire
%A Brennetot, Naima
%A Garne, Ester
%A Haddad, Georges
%A Hocine, Mounia
%A Lacroix, Isabelle
%A Leuraud, Klervi
%A Mench, Michel
%A Morris, Joan
%A Patrier, Sophie
%A Sartelet, Arnaud
%A Verloes, Alain
%A Bonaldi, Christophe
%A Le Barbier, Mélina
%A Gagnière, Bertrand
%A Pépin, Philippe
%A Ollivier, Ronan
%A Bitoun, Monique
%A King, Lisa
%A Guajardo-Villar, Andrea
%A Gomes, Eugenia
%A Desenclos, Jean-Claude
%A Regnault, Nolwenn
%A Benachi, Alexandra
%< avec comité de lecture
%@ 0393-2990
%J European Journal of Epidemiology
%I Springer Verlag
%8 2024-04-27
%D 2024
%R 10.1007/s10654-024-01125-5
%M 38671254
%K Birth defects
%K Cluster
%K Congenital anomalies
%K Environment
%K Limb reduction defects
%K Spatiotemporal analyses
%Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles
%X Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had not identified any risk exposure. We share here the national approach we developed for managing suspicious clusters of the same group of congenital anomalies occurring in several areas. Methods: The SEC analysed the medical records of TURLD suspected cases and performed spatiotemporal analyses on confirmed cases. If the cluster was statistically significant and included at least three cases, the SEC reviewed exposures obtained from questionnaires, environmental databases, and a survey among farmers living near to cases’ homes concerning their plant product use. Results: After case re-ascertainment, no statistically significant cluster was observed in the first administrative areas. In the second area, a cluster of four children born in two nearby towns over two years was confirmed, but as with the initial investigations, no exposure to a known risk factor explaining the number of cases in excess was identified. In the third area, a cluster including just two cases born the same year in the same town was confirmed. Discussion: Our experience highlights that in the event of suspicious clusters occurring in different areas of a country, a coordinated and standardised approach should be preferred
%G English
%L anses-04573454
%U https://anses.hal.science/anses-04573454
%~ UNIV-ST-ETIENNE
%~ IRSN
%~ ANSES
%~ INSTITUT-TELECOM
%~ EPHE
%~ UNIV-TLSE3
%~ UGA
%~ CNRS
%~ CNAM
%~ APHP
%~ INVS
%~ SANTE_PUB_INSERM
%~ HL
%~ CORDELIERS
%~ COMUE-NORMANDIE
%~ PSL
%~ AGREENIUM
%~ UNIV-LILLE
%~ SORBONNE-UNIVERSITE
%~ SORBONNE-UNIV
%~ SU-SCIENCES
%~ MESURS
%~ TEST-DEV
%~ UDL
%~ INSTITUTS-TELECOM
%~ INRAE
%~ UNIV-PARIS
%~ UNIVERSITE-PARIS
%~ UP-SANTE
%~ EPHE-PSL
%~ UGA-EPE
%~ U1219
%~ BIOGECO
%~ ALLIANCE-SU
%~ UNIV-UT3
%~ UT3-INP
%~ UT3-TOULOUSEINP
%~ PSESANTE
%~ HESAM-CNAM
%~ HESAM
%~ SESANE
%~ CERPOP
%~ DPT_ECODIV
%~ CERPOP-SPHERE