The first Rumiko Takahashi related anime to not be adapted from a pre-existing manga.
Due to the passing away of Kôji Tsujitani, Makoto Yasumura replaces him as the voice of Miroku for the Japanese version. Coincidentally his original English voice actor Kirby Morrow would pass away after he reprised his role for the first episode Are kara no Inuyasha (2020), and was replaced by Ian James Corlett starting with the thirteenth episode Sengoku oishî hôshi (2020).
This series marks the return of Sesshomaru's original English voice actor David Kaye for the English version. Previously he voiced Sesshomaru in most of the previous English version productions such as the original anime series (Inuyasha (2000)), movies, and video games. Due to his moving to California, the only previous production he could not be involved with was with the second anime series (InuYasha: Kanketsu-hen (2009)) and was replaced in that series by Michael Daingerfield.
The series takes place 22 years after Naraku's defeat. Kagome is about 37, Sango 38, Miroku 40, Kaede 80 and Rin 30.
In this series, Moroha is Inuyasha & Kagome's daughter; and Setsuna and Towa are Sesshomaru and Rin's twin daughters. Moroha, Setsuna, and Towa are blood-related cousins, due to their demonic fathers' family line. Hisui is Miroku and Sango's youngest son, aside from their elder twin daughters.