Abstract
Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesions in a hitherto uncharacterized gene we named Enigma. We show that Enigma encodes a mitochondrial protein with homology to enzymes of the beta-oxidation of fatty acids and that mutations in this locus affect lipid homeostasis. Our analysis provides further support to the notion that lipid metabolism may play a central role in metazoan lifespan regulation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Alleles
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Animals
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Cytoskeletal Proteins
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Drosophila Proteins / metabolism
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Drosophila Proteins / physiology*
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Drosophila melanogaster
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Gene Expression Regulation, Developmental
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Homozygote
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Intracellular Signaling Peptides and Proteins / physiology*
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LIM Domain Proteins
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Lipids / chemistry
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Microscopy, Fluorescence
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Mitochondria / metabolism*
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Mitochondrial Proteins / metabolism
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Mitochondrial Proteins / physiology*
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Models, Genetic
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Mutation
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Oligonucleotide Array Sequence Analysis
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Oxidative Stress*
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Oxygen / metabolism
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Paraquat / pharmacology
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Phenotype
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RNA Interference
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Subcellular Fractions
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Time Factors
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Triglycerides / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Cytoskeletal Proteins
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Drosophila Proteins
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Intracellular Signaling Peptides and Proteins
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LIM Domain Proteins
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Lipids
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Mitochondrial Proteins
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PDLIM7 protein, human
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Triglycerides
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egm protein, Drosophila
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Paraquat
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Oxygen