The ability to visualize endogenous proteins in living neurons provides a powerful means to
interrogate neuronal structure and function. Here we generate recombinant antibody-like …

Styrene dyes are useful imaging probes and fluorescent sensors due to their strong
fluorogenic responses to environmental changes or binding macromolecules. Previously …

Type 2 diabetes is characterized by β and α cell dysfunction. We used phasor-FLIM
(Fluorescence Lifetime Imaging Microscopy) to monitor oxidative phosphorylation and …

Cellular senescence is a mechanism by which cells permanently withdraw from the cell
cycle in response to stresses including telomere shortening, DNA damage, or oncogenic …

Although neuronal activity can be modulated using a variety of techniques, there are
currently few methods for controlling neuronal connectivity. We introduce a tool (GFE3) that …

Genetic mutations have long been recognized as drivers of cancer drug resistance, but
recent work has defined additional non-genetic mechanisms of plasticity, wherein cancer …

Background We previously reported developing 2 anticapsular monoclonal antibodies
(mAbs) as a novel therapy for Acinetobacter baumannii infections. We sought to determine …

Vertebrate embryogenesis and organogenesis are driven by cell biological processes,
ranging from mitosis and migration to changes in cell size and polarity, but their control and …

Fluorescence lifetime imaging microscopy (FLIM) evaluates the metabolic state of tissue
based on reduced nicotinamide adenine dinucleotide (NAD (P) H) and flavin adenine …

Sjögren's syndrome (SS) is an autoimmune disease associated with severe exocrinopathy,
which is characterized by profound lymphocytic infiltration (dacryoadenitis) and loss of …